0402: Angiopoietin-like 4 serum levels on admission for acute myocardial infarction are associated with no-reflow

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Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.

BACKGROUND Increased permeability, predominantly controlled by endothelial junction stability, is an early event in the deterioration of vascular integrity in ischemic disorders. Hemorrhage, edema, and inflammation are the main features of reperfusion injuries, as observed in acute myocardial infarction (AMI). Thus, preservation of vascular integrity is fundamental in ischemic heart disease. An...

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No-Reflow Phoenomenon by Intracoronary Thrombus in Acute Myocardial Infarction

Recently, percutaneous coronary intervention has been the treatment of choice in most acute myocardial infarction cases. Although the results of percutaneous coronary interventions have ben good, the no-reflow phenomenon and distal embolization of intracoronary thrombus are still major problems even after successful interventions. In this article, we will briefly review the deleterious effects ...

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Hyperglycemia and no-reflow phenomenon in acute myocardial infarction.

Phenomenon in Acute Myocardial Infarction Dr. Iwakura and colleagues in a recent issue of the Journal (1) conclude that, from a retrospective analysis of 146 patients, hyperglycemia might be associated with impaired microvascular function after acute myocardial infarction. The investigators describe an independent relation between elevated blood glucose levels on admission and no-reflow phenome...

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High plasma aldosterone levels on admission are associated with death in patients presenting with acute ST-elevation myocardial infarction.

BACKGROUND Aldosterone, the final mediator of the renin-angiotensin-aldosterone pathway, is at its highest plasma levels at presentation for ST-elevation myocardial infarction (STEMI). Whether aldosterone level at presentation for STEMI is associated with adverse outcome remains unknown. METHODS AND RESULTS Plasma aldosterone levels were measured at presentation in consecutive patients referr...

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Effects of tirofiban on the reperfusion-related no-reflow in rats with acute myocardial infarction

OBJECTIVE To investigate the effects of tirofiban on the no-reflow phenomenon of acute myocardial infarction (AMI) rats received reperfusion, as well as the underlying mechanisms. METHODS Fifty-six male Sprague-Dawley rats were randomly divided into four groups: Sham operation group (Sham), AMI/reperfusion group (AMI/R), Tirofiban group (Tiro) and Tiro+N-nitro-L-arginine group (L-NNA; an endo...

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ژورنال

عنوان ژورنال: Archives of Cardiovascular Diseases Supplements

سال: 2014

ISSN: 1878-6480

DOI: 10.1016/s1878-6480(14)71338-2